modelRamucirumab
Extends from Pharmacolibrary.Drugs.ATC.L.L01FG02.
Information
| name: | Ramucirumab | |
| ATC code: | L01FG02 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 800 | mg |
| volume of distribution: | 5.4 | L |
| clearance: | 0.0146 | L/h |
| other parameters in model implementation | ||
Ramucirumab is a fully human IgG1 monoclonal antibody that targets the vascular endothelial growth factor receptor-2 (VEGFR-2), inhibiting angiogenesis. It is used and approved for the treatment of various advanced cancers, including gastric cancer, non-small cell lung cancer, and colorectal cancer, most often in combination with other chemotherapeutic agents.
Pharmacokinetics
Pharmacokinetic parameters reported for adult cancer patients, both sexes, after intravenous infusion as monotherapy or in combination. Parameters are population pharmacokinetics from clinical trials in cancer populations.
References
O'Brien, L, et al., & Heathman, M (2017). Population pharmacokinetic meta-analysis of ramucirumab in cancer patients. British journal of clinical pharmacology 83(12) 2741–2751. DOI:10.1111/bcp.13403 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28833321
Gao, L, et al., & Abada, P (2021). Evaluating clinical impact of a shortened infusion duration for ramucirumab: a model-based approach. Cancer chemotherapy and pharmacology 87(5) 635–645. DOI:10.1007/s00280-020-04223-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33532866
Cao, J, et al., & Li, J (2017). Phase I Dose-Escalation Study of Ramucirumab in Chinese Patients with Advanced Solid Tumors. The oncologist 22(6) 638–e56. DOI:10.1634/theoncologist.2017-0137 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28465370
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)