.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01X_OtherAntineoplasticAgents.L01XA02_Carboplatin.Carboplatin

Information

name:Carboplatin
ATC code:L01XA02
route:intravenous
n-compartments2

Carboplatin is a platinum-based chemotherapy drug commonly used for the treatment of various cancers, including ovarian, lung, head and neck, and testicular cancers. It interferes with DNA replication in cancer cells, resulting in cell death. Carboplatin is widely approved and used in clinical oncology today.

Pharmacokinetics

Pharmacokinetics reported for adult cancer patients with normal renal function. Population PK analysis. Intravenous infusion over 60 minutes.

References

  1. Chatelut, E, et al., & Canal, P (1996). Population pharmacokinetics of carboplatin in children. Clinical pharmacology and therapeutics 59(4) 436–443. DOI:10.1016/S0009-9236(96)90113-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8612389

  2. Ozols, RF, et al., & Baergen, R (2003). Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 21(17) 3194–3200. DOI:10.1200/JCO.2003.02.153 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12860964

  3. Sonabend, AM, et al., & Stupp, R (2023). Repeated blood-brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase 1 trial. The Lancet. Oncology 24(5) 509–522. DOI:10.1016/S1470-2045(23)00112-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37142373

Revisions


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