.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01X_OtherAntineoplasticAgents.L01XH03_Panobinostat.Panobinostat .Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01X_OtherAntineoplasticAgents.L01XH03_Panobinostat.Panobinostat| name: | Panobinostat |
| ATC code: | L01XH03 | route: | oral |
| n-compartments | 2 |
Panobinostat is a potent pan-deacetylase inhibitor approved for the treatment of multiple myeloma, typically used in combination with other agents in patients who have received prior treatments. It is administered orally and acts by inhibiting histone deacetylases, thereby inducing apoptosis and cell cycle arrest in malignant cells.
Pharmacokinetics in adult patients with advanced hematologic malignancies after oral administration.
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Monje, M, et al., & Warren, KE (2023). Phase I trial of panobinostat in children with diffuse intrinsic pontine glioma: A report from the Pediatric Brain Tumor Consortium (PBTC-047). Neuro-oncology 25(12) 2262–2272. DOI:10.1093/neuonc/noad141 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37526549
Fukutomi, A, et al., & Yamamoto, N (2012). A phase I study of oral panobinostat (LBH589) in Japanese patients with advanced solid tumors. Investigational new drugs 30(3) 1096–1106. DOI:10.1007/s10637-011-9666-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21484248