modelPegaspargase
Extends from Pharmacolibrary.Drugs.ATC.L.L01XX24.
Information
| name: | Pegaspargase | |
| ATC code: | L01XX24 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 2500 | mg |
| volume of distribution: | 1.86 | L |
| clearance: | 0.167 | L/h/m2 |
| other parameters in model implementation | ||
Pegaspargase is a pegylated form of the enzyme L-asparaginase, used as an antineoplastic agent in the treatment of acute lymphoblastic leukemia (ALL) in pediatric and adult patients. It depletes asparagine, an amino acid essential to leukemic cells but not to normal cells, leading to selective cytotoxicity. Pegylation extends the half-life and reduces immunogenicity compared to native L-asparaginase. Pegaspargase is approved for clinical use in several countries including the US and EU.
Pharmacokinetics
Pharmacokinetic parameters reported in pediatric and adolescent patients with ALL (median age ~10 years) after single intravenous dose 2500 IU/m2.
References
Douer, D, et al., & Avramis, VI (2007). Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukemia. Blood 109(7) 2744–2750. DOI:10.1182/blood-2006-07-035006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17132721
Würthwein, G, et al., & Boos, J (2021). Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data. European journal of drug metabolism and pharmacokinetics 46(2) 289–300. DOI:10.1007/s13318-021-00670-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33595793
Würthwein, G, et al., & Boos, J (2017). Population Pharmacokinetics to Model the Time-Varying Clearance of the PEGylated Asparaginase Oncaspar. European journal of drug metabolism and pharmacokinetics 42(6) 955–963. DOI:10.1007/s13318-017-0410-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28349335
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)