.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01X_OtherAntineoplasticAgents.L01XX33_Celecoxib.Celecoxib

Information

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor nonsteroidal anti-inflammatory drug (NSAID) used primarily for the relief of pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain. It is widely approved and available in multiple countries for these indications.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects, both sexes, after single oral dose administration.

References

1. Dhondt, L, et al., & Antonissen, G (2017). Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus). Scientific reports 7(1) 12043–None. DOI:10.1038/s41598-017-12159-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/28947805

2. Kim, SH, et al., & Lee, SY (2017). Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metabolite. Archives of pharmacal research 40(3) 382–390. DOI:10.1007/s12272-016-0861-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27864660

3. Dooner, H, et al., & Smith, K (2019). Pharmacokinetics of Tramadol and Celecoxib in Japanese and Caucasian Subjects Following Administration of Co-Crystal of Tramadol-Celecoxib (CTC): A Randomised, Open-Label Study. European journal of drug metabolism and pharmacokinetics 44(1) 63–75. DOI:10.1007/s13318-018-0491-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29956215

Revisions

• 06/2025 initial generated model