.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L01X_OtherAntineoplasticAgents.L01XX66_Selinexor.Selinexor

Information

Selinexor is a selective inhibitor of nuclear export (SINE) that binds to and inhibits exportin 1 (XPO1). By blocking XPO1, selinexor leads to the nuclear retention and activation of tumor suppressor proteins, thereby causing cell cycle arrest and apoptosis in malignant cells. Selinexor is approved for the treatment of relapsed or refractory multiple myeloma and relapsed or refractory diffuse large B-cell lymphoma.

Pharmacokinetics

Pharmacokinetic model parameters for selinexor in adult patients with advanced solid tumors and hematologic malignancies. Parameters based on population pharmacokinetic analysis in relapsed/refractory multiple myeloma (mostly adults, both sexes).

References

1. Bader, JC, et al., & Xu, H (2021). Pharmacokinetics of Selinexor: The First-in-Class Selective Inhibitor of Nuclear Export. Clinical pharmacokinetics 60(8) 957–969. DOI:10.1007/s40262-021-01016-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/33928519

2. Podar, K, et al., & Jagannath, S (2020). Selinexor for the treatment of multiple myeloma. Expert opinion on pharmacotherapy 21(4) 399–408. DOI:10.1080/14656566.2019.1707184 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31957504

3. Rubinstein, MM, et al., & Makker, V (2021). A phase I open-label study of selinexor with paclitaxel and carboplatin in patients with advanced ovarian or endometrial cancers. Gynecologic oncology 160(1) 71–76. DOI:10.1016/j.ygyno.2020.10.019 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33139041

Revisions

• 06/2025 initial generated model