.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L02A_HormonesAndRelatedAgents.L02AB01_Megestrol.Megestrol .Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L02A_HormonesAndRelatedAgents.L02AB01_Megestrol.Megestrol| name: | Megestrol |
| ATC code: | L02AB01 | route: | oral |
| n-compartments | 1 |
Megestrol is a synthetic derivative of the hormone progesterone. It is mainly used as an appetite stimulant in conditions such as cachexia or anorexia associated with cancer or AIDS. It has also been used for the treatment of certain hormonally responsive cancers, such as breast and endometrial carcinoma. Megestrol acetate is approved in several countries for these indications.
Pharmacokinetic parameters reported in adult cancer patients following oral administration of megestrol acetate.
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Post, TM, et al., & de Greef, R (2016). Prediction of nomegestrol acetate pharmacokinetics in healthy female adolescents and adults by whole-body physiology-based pharmacokinetic modelling and clinical validation. Contraception 93(2) 133–138. DOI:10.1016/j.contraception.2015.08.017 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26365792
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