.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L02A_HormonesAndRelatedAgents.L02AB02_Medroxyprogesterone.Medroxyprogesterone

Information

Medroxyprogesterone is a synthetic progestogen (progestin) used primarily in hormone therapy, contraception, the treatment of endometriosis, and certain cancers. It is available in oral, intramuscular, and subcutaneous forms. Medroxyprogesterone acetate (MPA) is the most common ester and is widely approved for medical use.

Pharmacokinetics

Pharmacokinetic parameters refer to healthy female volunteers after a single intramuscular injection of medroxyprogesterone acetate (MPA), generally corresponding to depot contraceptive administration.

References

1. Zhou, XF, et al., & Sang, GW (1998). Pharmacokinetics of medroxyprogesterone acetate after single and multiple injection of Cyclofem in Chinese women. Contraception 57(6) 405–411. DOI:10.1016/s0010-7824(98)00048-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9693401

2. Zahradnik, HP (1995). [Depot gestagens]. Archives of gynecology and obstetrics 257(1-4) 536–541. DOI:10.1007/BF02264884 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8579439

3. Longo, N, et al., & Sile, S (2014). Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial. Lancet (London, England) 384(9937) 37–44. DOI:10.1016/S0140-6736(13)61841-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24743000

Revisions

• 06/2025 initial generated model