modelTriptorelin
Extends from Pharmacolibrary.Drugs.ATC.L.L02AE04.
Information
| name: | Triptorelin | |
| ATC code: | L02AE04 | route: | intramuscular |
| compartments: | 1 | |
| dosage: | 3.75 | mg |
| volume of distribution: | 29.2 | L |
| clearance: | 1.54 | L/h |
| other parameters in model implementation | ||
Triptorelin is a synthetic decapeptide agonist analogue of gonadotropin-releasing hormone (GnRH), used primarily for the treatment of advanced prostate cancer, central precocious puberty, endometriosis, and uterine fibroids. It works by suppressing pituitary gonadotropin secretion, thus lowering sex hormone levels. Triptorelin is approved and in use today as a depot injection in various indications.
Pharmacokinetics
Pharmacokinetic parameters in adult males with advanced prostate cancer following single intramuscular dose of 3.75 mg depot formulation; non-compartmental analysis.
References
Romero, E, et al., & Trocóniz, IF (2012). Pharmacokinetic/pharmacodynamic model of the testosterone effects of triptorelin administered in sustained release formulations in patients with prostate cancer. The Journal of pharmacology and experimental therapeutics 342(3) 788–798. DOI:10.1124/jpet.112.195560 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22691297
Tornøe, CW, et al., & Jonsson, EN (2007). Population pharmacokinetic/pharmacodynamic (PK/PD) modelling of the hypothalamic-pituitary-gonadal axis following treatment with GnRH analogues. British journal of clinical pharmacology 63(6) 648–664. DOI:10.1111/j.1365-2125.2006.02820.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/17096678
Lundström, EA, et al., & Porchet, HC (2009). Triptorelin 6-month formulation in the management of patients with locally advanced and metastatic prostate cancer: an open-label, non-comparative, multicentre, phase III study. Clinical drug investigation 29(12) 757–765. DOI:10.2165/11319690-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19888782
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)