.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L02B_HormoneAntagonistsAndRelatedAgents.L02BA01_Tamoxifen.Tamoxifen

Information

name:Tamoxifen
ATC code:L02BA01
route:oral
n-compartments2

Tamoxifen is a selective estrogen receptor modulator (SERM) widely used in the treatment and prevention of breast cancer, particularly hormone receptor-positive breast cancer. It remains a standard of care for pre-menopausal and post-menopausal women and is approved and in clinical use worldwide.

Pharmacokinetics

Pharmacokinetic parameters in healthy female volunteers, assessed after a single oral dose.

References

  1. Koubek, EJ, et al., & Reid, JM (2022). Population Pharmacokinetics of Z-Endoxifen in Patients With Advanced Solid Tumors. Journal of clinical pharmacology 62(9) 1121–1131. DOI:10.1002/jcph.2053 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35358345

  2. Ducharme, J, et al., & Wainer, IW (1997). Tamoxifen metabolic patterns within a glioma patient population treated with high-dose tamoxifen. British journal of clinical pharmacology 43(2) 189–193. DOI:10.1046/j.1365-2125.1997.05029.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/9131952

  3. Skirvin, JA, & Lichtman, SM (2002). Pharmacokinetic considerations of oral chemotherapy in elderly patients with cancer. Drugs & aging 19(1) 25–42. DOI:10.2165/00002512-200219010-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11929325

Revisions


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