modelDegarelix
Extends from Pharmacolibrary.Drugs.ATC.L.L02BX02.
Information
| name: | Degarelix | |
| ATC code: | L02BX02 | route: | subcutaneous |
| compartments: | 2 | |
| dosage: | 240 | mg |
| volume of distribution: | 19 | L |
| clearance: | 0.88 | L/h |
| other parameters in model implementation | ||
Degarelix is a selective gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of advanced hormone-dependent prostate cancer in men. It acts by suppressing the production of luteinizing hormone and subsequently testosterone without causing a testosterone surge. Degarelix is currently approved for medical use in many countries for prostate cancer.
Pharmacokinetics
Pharmacokinetic parameters reported in adult males with prostate cancer following subcutaneous administration.
References
Tornøe, CW, et al., & Jonsson, EN (2004). Population pharmacokinetic modeling of a subcutaneous depot for GnRH antagonist degarelix. Pharmaceutical research 21(4) 574–584. DOI:10.1023/b:pham.0000022403.60314.51 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15139513
Tornøe, CW, et al., & Jonsson, EN (2007). Population pharmacokinetic/pharmacodynamic (PK/PD) modelling of the hypothalamic-pituitary-gonadal axis following treatment with GnRH analogues. British journal of clinical pharmacology 63(6) 648–664. DOI:10.1111/j.1365-2125.2006.02820.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/17096678
Tornøe, CW, et al., & Jonsson, EN (2005). Stochastic differential equations in NONMEM: implementation, application, and comparison with ordinary differential equations. Pharmaceutical research 22(8) 1247–1258. DOI:10.1007/s11095-005-5269-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16078134
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)