.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L04A_Immunosuppressants.L04AA40_Cladribine.Cladribine

Information

Cladribine is a purine nucleoside analog used as an antineoplastic and immunosuppressive agent. It is primarily indicated for the treatment of hairy cell leukemia and, more recently, approved for relapsing forms of multiple sclerosis in adults. Cladribine is approved and used in various countries for these indications.

Pharmacokinetics

Pharmacokinetic parameters reported in adult patients with multiple sclerosis after oral administration of cladribine tablets.

References

1. Savic, RM, et al., & Karlsson, MO (2017). Population Pharmacokinetics of Cladribine in Patients with Multiple Sclerosis. Clinical pharmacokinetics 56(10) 1245–1253. DOI:10.1007/s40262-017-0516-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28255849

2. Lindemalm, S, et al., & Albertioni, F (2005). Application of population pharmacokinetics to cladribine. BMC pharmacology 5 4–None. DOI:10.1186/1471-2210-5-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15757511

3. Meuth, SG, et al., & Hartung, HP (2018). [Cladribine tablets : Oral immunotherapy of relapsing-remitting multiple sclerosis with short yearly treatment periods]. Der Nervenarzt 89(8) 895–907. DOI:10.1007/s00115-018-0498-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29523912

Revisions

• 06/2025 initial generated model