.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L04A_Immunosuppressants.L04AC15_Sirukumab.Sirukumab .Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L04A_Immunosuppressants.L04AC15_Sirukumab.Sirukumab| name: | Sirukumab |
| ATC code: | L04AC15 | route: | subcutaneous |
| n-compartments | 2 |
Sirukumab is a human monoclonal antibody that binds to and inhibits interleukin-6 (IL-6), a cytokine involved in inflammatory processes. It was developed for the treatment of autoimmune conditions, particularly rheumatoid arthritis. Although it showed efficacy, it is not currently approved for clinical use due to safety concerns and unfavorable risk-benefit evaluation.
Pharmacokinetic parameters reported from phase 3 studies in adult patients with moderate-to-severe rheumatoid arthritis.
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