.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L04A_Immunosuppressants.L04AD01_Ciclosporin.Ciclosporin

Information

Ciclosporin (also known as cyclosporine) is a calcineurin inhibitor immunosuppressant primarily used to prevent organ transplant rejection and to treat autoimmune diseases such as rheumatoid arthritis and psoriasis. It is approved for use in many countries and remains an important drug in transplant medicine.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers following oral administration; parameters are population means reported in published literature.

References

1. Fruit, D, et al., & Prémaud, A (2013). Ciclosporin population pharmacokinetics and Bayesian estimation in thoracic transplant recipients. Clinical pharmacokinetics 52(4) 277–288. DOI:10.1007/s40262-013-0037-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/23400901

2. Ling, J, et al., & Chen, R (2022). Population pharmacokinetics of ciclosporin in allogeneic hematopoietic stem cell transplant recipients: C-reactive protein as a novel covariate for clearance. Journal of clinical pharmacy and therapeutics 47(4) 483–492. DOI:10.1111/jcpt.13569 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34779003

3. Wilhelm, AJ, et al., & Swart, EL (2012). Population pharmacokinetics of ciclosporin in haematopoietic allogeneic stem cell transplantation with emphasis on limited sampling strategy. British journal of clinical pharmacology 73(4) 553–563. DOI:10.1111/j.1365-2125.2011.04116.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/21988410

Revisions

• 06/2025 initial generated model