.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L04A_Immunosuppressants.L04AF06_Peficitinib.Peficitinib

Information

Peficitinib is an oral Janus kinase (JAK) inhibitor developed for the treatment of rheumatoid arthritis. It works by inhibiting signaling pathways involved in inflammation and immune response. Peficitinib is approved for use in Japan and several other countries for patients with moderate to severe rheumatoid arthritis who have had an inadequate response to other disease-modifying antirheumatic drugs (DMARDs).

Pharmacokinetics

Pharmacokinetics in healthy adult volunteers following single and multiple oral doses; parameters are typical for adult, non-elderly, mostly Asian subjects.

References

1. Miyatake, D, et al., & Urae, A (2020). Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects With Normal and Impaired Hepatic Function. Clinical pharmacology in drug development 9(6) 699–708. DOI:10.1002/cpdd.751 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31833184

2. Shibata, M, et al., & Nishimura, T (2020). Pharmacokinetics, Pharmacodynamics, and Safety of Peficitinib (ASP015K) in Healthy Male Caucasian and Japanese Subjects. Clinical drug investigation 40(5) 469–484. DOI:10.1007/s40261-020-00910-w PUBMED:https://pubmed.ncbi.nlm.nih.gov/32274653

Revisions

• 06/2025 initial generated model