.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L04A_Immunosuppressants.L04AJ02_Ravulizumab.Ravulizumab .Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L04A_Immunosuppressants.L04AJ02_Ravulizumab.Ravulizumab| name: | Ravulizumab |
| ATC code: | L04AJ02 | route: | intravenous |
| n-compartments | 2 |
Ravulizumab is a recombinant humanized monoclonal antibody that inhibits the complement protein C5. It is used intravenously for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) in adults and children. It is an FDA- and EMA-approved drug, offering extended-duration complement inhibition.
Population pharmacokinetics in adult patients with PNH following intravenous dosing; model applies to both sexes, typical adult patient.
Cosson, V, et al., & Buatois, S (2025). Pharmacokinetic characterization and exposure-response relationship of crovalimab in the COMMODORE 1, 2 and 3 and COMPOSER trials of patients with paroxysmal nocturnal haemoglobinuria. British journal of clinical pharmacology 91(5) 1479–1490. DOI:10.1111/bcp.16394 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39835421