.Pharmacolibrary.Drugs.L_AntineoplasticAndImmunomodulatingAgents.L04A_Immunosuppressants.L04AX02_Thalidomide.Thalidomide

Information

name:Thalidomide
ATC code:L04AX02
route:oral
n-compartments1

Thalidomide is an immunomodulatory drug originally developed as a sedative, later infamous for causing birth defects. It is now approved in several countries, including the United States, as part of treatment for multiple myeloma and for erythema nodosum leprosum (ENL) associated with leprosy. Thalidomide exhibits anti-inflammatory, anti-angiogenic, and immunomodulatory effects.

Pharmacokinetics

Pharmacokinetics in healthy adult males after a single oral dose.

References

  1. Teo, SK, et al., & Laskin, OL (2004). Clinical pharmacokinetics of thalidomide. Clinical pharmacokinetics 43(5) 311–327. DOI:10.2165/00003088-200443050-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15080764

  2. Gaudy, A, et al., & Chen, N (2020). Population Pharmacokinetic Model to Assess the Impact of Disease State on Thalidomide Pharmacokinetics. Journal of clinical pharmacology 60(1) 67–74. DOI:10.1002/jcph.1506 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31392755

  3. Figg, WD, et al., & Reed, E (1999). Pharmacokinetics of thalidomide in an elderly prostate cancer population. Journal of pharmaceutical sciences 88(1) 121–125. DOI:10.1021/js980172i PUBMED:https://pubmed.ncbi.nlm.nih.gov/9874712

Revisions


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