.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M01A_AntiinflammatoryAndAntirheumaticProductsNonStero.M01AA01_Phenylbutazone.Phenylbutazone

Information

Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties, previously widely used for the treatment of pain and inflammation related to arthritis and gout. Due to its significant side effect profile, especially risk of agranulocytosis and aplastic anemia, its human use is now severely restricted or withdrawn in many countries, though it remains in use in veterinary medicine.

Pharmacokinetics

Healthy adult volunteers, single oral dose pharmacokinetics

References

1. Houck, EL, et al., & Delk, KW (2022). Phenylbutazone pharmacokinetics in southern white rhinoceros (Ceratotherium simum simum) after oral administration. Journal of veterinary pharmacology and therapeutics 45(2) 196–202. DOI:10.1111/jvp.13036 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34894412

2. Chay, S, et al., & Yocum, J (1984). Population distributions of phenylbutazone and oxyphenbutazone after oral and i.v. dosing in horses. Journal of veterinary pharmacology and therapeutics 7(4) 265–276. DOI:10.1111/j.1365-2885.1984.tb00911.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/6512917

3. Knych, HK, et al., & Kass, PH (2016). Pharmacokinetics of methocarbamol and phenylbutazone in exercised Thoroughbred horses. Journal of veterinary pharmacology and therapeutics 39(5) 469–477. DOI:10.1111/jvp.12298 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26924025

Revisions

• 06/2025 initial generated model