.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M01A_AntiinflammatoryAndAntirheumaticProductsNonStero.M01AA03_Oxyphenbutazone.Oxyphenbutazone

Information

name:Oxyphenbutazone
ATC code:M01AA03
route:oral
n-compartments2

Oxyphenbutazone is a nonsteroidal anti-inflammatory drug (NSAID) of the pyrazolidinedione class, formerly used in the treatment of rheumatoid arthritis and other inflammatory conditions. Due to safety concerns, particularly risk of severe adverse hematological reactions such as agranulocytosis, the drug is no longer approved or widely used in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters are reported for healthy adult volunteers (sex not specified) following oral administration.

References

  1. Chay, S, et al., & Yocum, J (1984). Population distributions of phenylbutazone and oxyphenbutazone after oral and i.v. dosing in horses. Journal of veterinary pharmacology and therapeutics 7(4) 265–276. DOI:10.1111/j.1365-2885.1984.tb00911.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/6512917

  2. Brouwers, JR, & de Smet, PA (1994). Pharmacokinetic-pharmacodynamic drug interactions with nonsteroidal anti-inflammatory drugs. Clinical pharmacokinetics 27(6) 462–485. DOI:10.2165/00003088-199427060-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7882636

  3. Tobin, T, et al., & Lees, P (1986). Phenylbutazone in the horse: a review. Journal of veterinary pharmacology and therapeutics 9(1) 1–25. DOI:10.1111/j.1365-2885.1986.tb00008.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/3517382

Revisions


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