name: | Ketorolac |
ATC code: | M01AB15 | route: | intravenous |
n-compartments | 2 |
Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for the short-term treatment of moderate to severe pain. It is typically administered for post-operative pain management and is not recommended for long-term use due to potential side effects, particularly on the gastrointestinal tract and kidneys. Ketorolac is approved and used in clinical practice today.
Pharmacokinetic parameters reported for healthy adults after intravenous administration.
McLay, JS, et al., & Anderson, BJ (2018). The pharmacokinetics of intravenous ketorolac in children aged 2 months to 16 years: A population analysis. Paediatric anaesthesia 28(2) 80–86. DOI:10.1111/pan.13302 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29266539
Mohammed, BS, et al., & McLay, JS (2015). The enantioselective population pharmacokinetics of intravenous ketorolac in children using a stereoselective assay suitable for microanalysis. The Journal of pharmacy and pharmacology 67(9) 1179–1187. DOI:10.1111/jphp.12418 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25880462
Cohen, MN, et al., & Galinkin, J (2011). Pharmacokinetics of single-dose intravenous ketorolac in infants aged 2-11 months. Anesthesia and analgesia 112(3) 655–660. DOI:10.1213/ANE.0b013e3182075d04 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21233498