.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M01A_AntiinflammatoryAndAntirheumaticProductsNonStero.M01AC01_Piroxicam.Piroxicam

Information

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class, used primarily for the symptomatic treatment of rheumatoid arthritis and osteoarthritis, as well as for musculoskeletal pain and inflammation. It is approved for use in many countries for these indications.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after single oral dosing of piroxicam.

References

1. Palma-Aguirre, JA, et al., & González-de la Parra, M (2010). Relative bioavailability of two oral formulations of piroxicam 20 mg: a single-dose, randomized-sequence, open-label, two-period crossover comparison in healthy Mexican adult volunteers. Clinical therapeutics 32(2) 357–364. DOI:10.1016/j.clinthera.2010.02.002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20206793

2. Calvo, AM, et al., & Santos, CF (2016). Effective method for the detection of piroxicam in human plasma using HPLC. Brazilian oral research 30(1) –. DOI:10.1590/1807-3107BOR-2016.vol30.0058 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27223141

3. Mailhot, C, et al., & Ward, JR (1986). The effect of cimetidine on serum concentrations of piroxicam. Pharmacotherapy 6(3) 112–117. DOI:10.1002/j.1875-9114.1986.tb03464.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/3488542

Revisions

• 06/2025 initial generated model