.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M01A_AntiinflammatoryAndAntirheumaticProductsNonStero.M01AE01_Ibuprofen.Ibuprofen

Information

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for the relief of pain, fever, and inflammation. It is approved for use in many countries and is available both over-the-counter and by prescription for various indications including headache, dental pain, menstrual cramps, muscle aches, minor arthritis, and to reduce fever.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects following single oral dose administration.

References

1. Moore, RA, et al., & Straube, S (2015). Effects of food on pharmacokinetics of immediate release oral formulations of aspirin, dipyrone, paracetamol and NSAIDs - a systematic review. British journal of clinical pharmacology 80(3) 381–388. DOI:10.1111/bcp.12628 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25784216

2. Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834

3. Sharma, PK, et al., & Narang, A (2003). Pharmacokinetics of oral ibuprofen in premature infants. Journal of clinical pharmacology 43(9) 968–973. DOI:10.1177/0091270003254635 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12971028

Revisions

• 06/2025 initial generated model