.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M01A_AntiinflammatoryAndAntirheumaticProductsNonStero.M01AE52_NaproxenAndEsomeprazole.NaproxenAndEsomeprazole .Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M01A_AntiinflammatoryAndAntirheumaticProductsNonStero.M01AE52_NaproxenAndEsomeprazole.NaproxenAndEsomeprazole| name: | NaproxenAndEsomeprazole |
| ATC code: | M01AE52 | route: | oral |
| n-compartments | 1 |
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, inflammation, and fever. Esomeprazole is a proton pump inhibitor used to decrease gastric acid secretion. The combination is typically used to treat symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in patients at risk of NSAID-associated gastric ulcers. The fixed-dose combination is approved and used in clinical practice.
Estimated pharmacokinetic parameters for a fixed dose combination tablet as used in adults, based on available single agent PK literature due to lack of identified original popPK reference for the combination.
Choi, HG, et al., & Kim, MG (2015). Pharmacokinetic comparison study of a combination containing 500 mg of Naproxen and 20 mg of Esomeprazole: a randomized, single-dose, 2-way crossover, open-label study in healthy Korean men. Clinical therapeutics 37(1) 83–93. DOI:10.1016/j.clinthera.2014.11.004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25482305