.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M01A_AntiinflammatoryAndAntirheumaticProductsNonStero.M01AE57_NaproxenAndDiphenhydrami.NaproxenAndDiphenhydrami .Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M01A_AntiinflammatoryAndAntirheumaticProductsNonStero.M01AE57_NaproxenAndDiphenhydrami.NaproxenAndDiphenhydrami| name: | NaproxenAndDiphenhydramine | |
| ATC code: | M01AE57 | route: | oral |
| compartments: | 1 | |
| dosage: | 245 | mg |
| volume of distribution: | 13 | L |
| clearance: | 0.13 | L/h |
| other parameters in model implementation | ||
A fixed-dose combination of naproxen, a nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation, and diphenhydramine, a first-generation antihistamine primarily used for allergy symptoms and as a sleep aid. The combination is approved for short-term treatment of occasional sleeplessness associated with minor aches and pains in adults.
Pharmacokinetic parameters estimated for healthy adult subjects based on individual component data (naproxen 220 mg + diphenhydramine 25 mg orally), as no published clinical pharmacokinetic studies are available for the fixed combination product.