.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M01A_AntiinflammatoryAndAntirheumaticProductsNonStero.M01AH02_Rofecoxib.Rofecoxib

Information

name:Rofecoxib
ATC code:M01AH02
route:oral
n-compartments1

Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) of the selective COX-2 inhibitor class, previously marketed for the treatment of osteoarthritis, acute pain conditions, and dysmenorrhea. Its use has been discontinued worldwide due to concerns over increased risk of cardiovascular events.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers following single oral administration.

References

  1. Huntjens, DR, et al., & Della Pasqua, O (2008). Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats. British journal of pharmacology 153(5) 1072–1084. DOI:10.1038/sj.bjp.0707643 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18193075

  2. Burian, M, & Geisslinger, G (2003). [Clinical pharmacology of the selective COX-2 inhibitors]. Der Orthopade 32(12) 1078–1087. DOI:10.1007/s00132-003-0569-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14655004

Revisions


Generated at 2025-07-21T18:21:10Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos