.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M03A_MuscleRelaxantsPeripherallyActingAgents.M03AC03_Vecuronium.Vecuronium

Information

Vecuronium is a non-depolarizing neuromuscular blocker of the aminosteroid group, used as an adjunct to general anesthesia to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgery or mechanical ventilation. It is typically administered intravenously and is approved for clinical use.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult surgical patients following intravenous bolus administration.

References

1. Caldwell, JE, et al., & Sessler, DI (2000). Temperature-dependent pharmacokinetics and pharmacodynamics of vecuronium. Anesthesiology 92(1) 84–93. DOI:10.1097/00000542-200001000-00018 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10638903

2. Keating, GM (2016). Sugammadex: A Review of Neuromuscular Blockade Reversal. Drugs 76(10) 1041–1052. DOI:10.1007/s40265-016-0604-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27324403

3. Onrust, SV, & Foster, RH (1999). Rapacuronium bromide: a review of its use in anaesthetic practice. Drugs 58(5) 887–918. DOI:10.2165/00003495-199958050-00011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10595867

Revisions

• 06/2025 initial generated model