.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M03A_MuscleRelaxantsPeripherallyActingAgents.M03AC04_Atracurium.Atracurium

Information

Atracurium is a non-depolarizing neuromuscular blocking agent used to induce skeletal muscle relaxation during surgery or mechanical ventilation. It acts by competing with acetylcholine for nicotinic receptors at the neuromuscular junction. Atracurium is approved and widely used in clinical anesthesia.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult surgical patients (age 18-65) of both sexes undergoing general anesthesia.

References

1. Kisor, DF, & Schmith, VD (1999). Clinical pharmacokinetics of cisatracurium besilate. Clinical pharmacokinetics 36(1) 27–40. DOI:10.2165/00003088-199936010-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9989341

2. Dahaba, AA, et al., & Reibnegger, G (2022). Location matters: Overlooked ethnic-geographic effect in China and Austria on propofol/cisatracurium sex differences among a population pharmacokinetic/pharmacodynamic (PopPK/PD) covariate analysis in men, women, and one transgender subject. Fundamental & clinical pharmacology 36(1) 182–198. DOI:10.1111/fcp.12704 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34050969

3. Olkkola, KT, et al., & Apffelstaedt, C (1991). Model-based adaptive closed-loop feedback control of atracurium-induced neuromuscular blockade. Acta anaesthesiologica Scandinavica 35(5) 420–423. DOI:10.1111/j.1399-6576.1991.tb03321.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/1887743

Revisions

• 06/2025 initial generated model