.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M03A_MuscleRelaxantsPeripherallyActingAgents.M03AC09_RocuroniumBromide.RocuroniumBromide

Information

Rocuronium bromide is a non-depolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is approved and widely used in clinical anesthesia practice.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult patients (age range approx. 18-65 years) undergoing elective surgery, following single intravenous bolus dose.

References

1. Szenohradszky, J, et al., & Miller, RD (1992). Pharmacokinetics of rocuronium bromide (ORG 9426) in patients with normal renal function or patients undergoing cadaver renal transplantation. Anesthesiology 77(5) 899–904. DOI:10.1097/00000542-199211000-00010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1443743

2. Onrust, SV, & Foster, RH (1999). Rapacuronium bromide: a review of its use in anaesthetic practice. Drugs 58(5) 887–918. DOI:10.2165/00003495-199958050-00011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10595867

3. Kotake, Y, et al., & Iwao, Y (2006). [Randomized, multicenter study of interaction between Org 9426 (rocuronium bromide) and anesthetic agents in Japanese population]. Masui. The Japanese journal of anesthesiology 55(7) 873–879. PUBMED:https://pubmed.ncbi.nlm.nih.gov/16856548

Revisions

• 06/2025 initial generated model