.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M03B_MuscleRelaxantsCentrallyActingAgents.M03BX01_Baclofen.Baclofen

Information

Baclofen is a centrally acting skeletal muscle relaxant primarily used to treat spasticity due to multiple sclerosis, spinal cord injury, or other neurological conditions. It acts as a GABA-B receptor agonist and is an approved medication in many countries for the management of muscle spasticity.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects after single oral baclofen dose administration.

References

1. Chevillard, L, et al., & Declèves, X (2018). Population pharmacokinetics of oral baclofen at steady-state in alcoholic-dependent adult patients. Fundamental & clinical pharmacology 32(2) 239–248. DOI:10.1111/fcp.12330 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29091319

2. He, Y, et al., & Jusko, WJ (2014). Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy. The Journal of pediatrics 164(5) 1181–1188.e8. DOI:10.1016/j.jpeds.2014.01.029 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24607242

3. Wiersma, HE, et al., & Benninga, MA (2003). Pharmacokinetics of a single oral dose of baclofen in pediatric patients with gastroesophageal reflux disease. Therapeutic drug monitoring 25(1) 93–98. DOI:10.1097/00007691-200302000-00014 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12548151

Revisions

• 06/2025 initial generated model