.Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M09A_OtherDrugsForDisordersOfTheMusculoSkeletalSystem.M09AX01_HyaluronicAcid.HyaluronicAcid .Pharmacolibrary.Drugs.M_MusculoSkeletalSystem.M09A_OtherDrugsForDisordersOfTheMusculoSkeletalSystem.M09AX01_HyaluronicAcid.HyaluronicAcid| name: | HyaluronicAcid |
| ATC code: | M09AX01 | route: | intraarticular |
| n-compartments | 1 |
Hyaluronic acid is a naturally occurring glycosaminoglycan used in medicine for joint disorders (such as osteoarthritis), for intra-articular injections, ophthalmology (such as in cataract surgery), dermatology (as a dermal filler), and wound healing. Approved for use in many countries, its main approved parenteral uses are in osteoarthritis and ophthalmology.
No population pharmacokinetic models in humans following parenteral or oral administration are available in published literature. Hyaluronic acid is mostly used intra-articularly or topically; systemic PK after intra-articular administration in humans is not well described. Estimates are based on its known biological half-life, synovial fluid turnover, and animal studies.
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