.Pharmacolibrary.Drugs.N_NervousSystem.N01A_AnestheticsGeneral.N01AF01_Methohexital.Methohexital

Information

Methohexital is a short-acting barbiturate anesthetic primarily used for the induction of anesthesia and for procedural sedation, especially in short diagnostic or surgical procedures. It is currently approved and in use for induction of anesthesia, particularly in settings where rapid onset and short duration are desired, such as in electroconvulsive therapy (ECT).

Pharmacokinetics

Pharmacokinetic parameters from adults, healthy subjects, following single intravenous bolus administration.

References

1. Halbeck, E, et al., & Bolkenius, D (2018). [Drugs for intravenous induction of anesthesia: ketamine, midazolam and synopsis of current hypnotics]. Der Anaesthesist 67(8) 617–634. DOI:10.1007/s00101-018-0469-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30069734

2. Schwilden, H, et al., & Stoeckel, H (1987). Closed-loop feedback control of methohexital anesthesia by quantitative EEG analysis in humans. Anesthesiology 67(3) 341–347. DOI:10.1097/00000542-198709000-00011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3631609

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)