.Pharmacolibrary.Drugs.N_NervousSystem.N01A_AnestheticsGeneral.N01AX11_SodiumOxybate.SodiumOxybate

Information

Sodium oxybate is the sodium salt of gamma-hydroxybutyric acid (GHB), a central nervous system depressant primarily used in the treatment of narcolepsy, particularly for cataplexy and excessive daytime sleepiness. It is approved for medical use as an orphan drug in several countries, including the US and EU.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after oral administration of sodium oxybate.

References

1. Chen, C, et al., & Plazzi, G (2020). Population and Noncompartmental Pharmacokinetics of Sodium Oxybate Support Weight-Based Dosing in Children and Adolescents With Narcolepsy With Cataplexy. Clinical and translational science 13(5) 932–940. DOI:10.1111/cts.12780 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32216084

2. Schep, LJ, et al., & Mégarbane, B (2012). The clinical toxicology of γ-hydroxybutyrate, γ-butyrolactone and 1,4-butanediol. Clinical toxicology (Philadelphia, Pa.) 50(6) 458–470. DOI:10.3109/15563650.2012.702218 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22746383

3. Fung, HL, et al., & Mi Fung, S (2008). Pharmacokinetics of 1,4-butanediol in rats: bioactivation to gamma-hydroxybutyric acid, interaction with ethanol, and oral bioavailability. The AAPS journal 10(1) 56–69. DOI:10.1208/s12248-007-9006-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18446506

Revisions

• 06/2025 initial generated model