.Pharmacolibrary.Drugs.N_NervousSystem.N01B_AnestheticsLocal.N01BB02_Lidocaine.Lidocaine_1

Information

Lidocaine is a local anesthetic and antiarrhythmic drug widely used for the numbing of tissue in a specific area and for treating ventricular arrhythmias. It is approved for use today and commonly used in both minor surgical procedures and as an intravenous therapy for cardiac arrhythmias.

Pharmacokinetics

Pharmacokinetic parameters following oral administration in healthy adult volunteers.

References

1. Bebawy, G, et al., & Abdallah, OY (2024). Buccal lidocaine mucoadhesive patches for pediatrics' teething pain: overcoming possible hazards of oral gels. Pharmaceutical development and technology 29(8) 805–813. DOI:10.1080/10837450.2024.2393729 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39166264

2. Chow, MS, et al., & Hilleman, D (1988). Propafenone: a new antiarrhythmic agent. Clinical pharmacy 7(12) 869–877. PUBMED:https://pubmed.ncbi.nlm.nih.gov/3061720

3. Klotz, U (2007). Antiarrhythmics: elimination and dosage considerations in hepatic impairment. Clinical pharmacokinetics 46(12) 985–996. DOI:10.2165/00003088-200746120-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18027986

Revisions

• 06/2025 initial generated model