.Pharmacolibrary.Drugs.N_NervousSystem.N01B_AnestheticsLocal.N01BC01_Cocaine.Cocaine

Information

Cocaine is a tropane alkaloid and potent central nervous system stimulant, primarily known as a recreational drug with strong stimulant properties as well as a local anesthetic. Historically used in medicine for local anesthesia (especially in ophthalmic and oral/nasal surgery), it is now rarely used therapeutically due to its high abuse potential and is a controlled substance.

Pharmacokinetics

Pharmacokinetic parameters for cocaine after intravenous administration in healthy adult male volunteers (n=6), as reported in a two-compartment model.

References

1. Rook, EJ, et al., & Beijnen, JH (2006). Population pharmacokinetics of heroin and its major metabolites. Clinical pharmacokinetics 45(4) 401–417. DOI:10.2165/00003088-200645040-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16584286

2. van Amsterdam, J, & van den Brink, W (2025). Explaining the high mortality among opioid-cocaine co-users compared to opioid-only users. A systematic review. Journal of addictive diseases 43(2) 121–131. DOI:10.1080/10550887.2024.2331522 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38504419

3. Fattinger, K, et al., & Verotta, D (2000). Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine. European journal of clinical pharmacology 56(4) 305–310. DOI:10.1007/s002280000147 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10954344

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)