.Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AA03_Hydromorphone.Hydromorphone_1

Information

name:Hydromorphone_1
ATC code:N02AA03_1
route:intravenous
n-compartments2

Hydromorphone is a potent opioid analgesic used to relieve moderate to severe pain. It acts primarily as a mu-opioid receptor agonist and is approved for use in many countries. Hydromorphone is available in various formulations including oral, intravenous, and rectal preparations. It is commonly used in both acute and chronic pain management, particularly in hospital settings.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers following intravenous bolus administration.

References

  1. Balyan, R, et al., & Chidambaran, V (2020). Hydromorphone population pharmacokinetics in pediatric surgical patients. Paediatric anaesthesia 30(10) 1091–1101. DOI:10.1111/pan.13975 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32702184

  2. Nakatani, T, et al., & Saito, Y (2023). Steady-State Pharmacokinetics of Intravenous Hydromorphone in Japanese Patients With Renal Impairment and Cancer Pain. Journal of palliative medicine 26(6) 768–775. DOI:10.1089/jpm.2022.0289 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36579915

  3. Jeleazcov, C, et al., & Schüttler, J (2014). Population pharmacokinetic modeling of hydromorphone in cardiac surgery patients during postoperative pain therapy. Anesthesiology 120(2) 378–391. DOI:10.1097/ALN.0b013e3182a76d05 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23958818

Revisions


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