.Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AA53_HydromorphoneAndNaloxone.HydromorphoneAndNaloxone .Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AA53_HydromorphoneAndNaloxone.HydromorphoneAndNaloxone| name: | HydromorphoneAndNaloxone |
| ATC code: | N02AA53 | route: | oral |
| n-compartments | 1 |
Hydromorphone and naloxone is a fixed-dose combination used for the management of severe pain that requires opioid analgesia with reduced risk of opioid-induced constipation. Hydromorphone is a potent opioid agonist, while naloxone is an opioid antagonist intended to counteract opioid side effects locally in the gut. The combination is approved and used in some countries (e.g., the EU) for chronic severe pain.
Pharmacokinetic parameters are estimated based on available data for the individual components and the fixed combination. No direct population PK studies for the combination tablet were found. Estimates are based on published data for hydromorphone and for orally administered naloxone in healthy adults.
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