.Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AB03_Fentanyl.Fentanyl

Information

Fentanyl is a potent synthetic opioid analgesic used primarily for the management of acute and chronic pain, especially in perioperative settings, cancer pain, and in anesthesia. It is approved for medical use and is known for its high potency and rapid onset of action compared to morphine.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after intravenous administration.

References

1. Ziesenitz, VC, et al., & van den Anker, JN (2018). Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review. Clinical pharmacokinetics 57(2) 125–149. DOI:10.1007/s40262-017-0569-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28688027

2. Smith, HAB, et al., & Berkenbosch, JW (2022). 2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 23(2) e74–e110. DOI:10.1097/PCC.0000000000002873 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35119438

3. Saari, TI, et al., & Dale, O (2024). Clinical Pharmacokinetics and Pharmacodynamics of Naloxone. Clinical pharmacokinetics 63(4) 397–422. DOI:10.1007/s40262-024-01355-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38485851

Revisions

• 06/2025 initial generated model