.Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AE01_Buprenorphine.Buprenorphine_1

Information

name:Buprenorphine_1
ATC code:N02AE01_1
route:intravenous
n-compartments2

Buprenorphine is a semi-synthetic opioid used primarily for pain management and opioid dependence therapy. It acts as a partial agonist at mu-opioid receptors, providing analgesia and mitigating opioid withdrawal symptoms.

Pharmacokinetics

Pharmacokinetics after intravenous administration in healthy adults.

References

  1. Hakomäki, H, et al., & Kokki, M (2021). Pharmacokinetics of buprenorphine in pregnant sheep after intravenous injection. Pharmacology research & perspectives 9(2) e00726–None. DOI:10.1002/prp2.726 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33619904

  2. Jensen, ML, et al., & Christrup, L (2007). Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers. European journal of clinical pharmacology 63(12) 1153–1159. DOI:10.1007/s00228-007-0377-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17874319

  3. Pypendop, BH, et al., & Barter, LS (2023). Pharmacokinetics of buprenorphine and its metabolite norbuprenorphine in neutered male cats anesthetized with isoflurane. Veterinary anaesthesia and analgesia 50(4) 349–355. DOI:10.1016/j.vaa.2023.04.004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37270407

Revisions


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