.Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AJ15_TramadolAndOtherNonOpioi.TramadolAndOtherNonOpioi .Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AJ15_TramadolAndOtherNonOpioi.TramadolAndOtherNonOpioi| name: | TramadolAndOtherNonOpioidAnalgesics | |
| ATC code: | N02AJ15 | route: | oral |
| compartments: | 2 | |
| dosage: | 100 | mg |
| volume of distribution: | 2.7 | L |
| clearance: | 0.3 | L/h/kg |
| other parameters in model implementation | ||
Combination of tramadol, an opioid analgesic with both opioid receptor agonist and monoaminergic reuptake inhibition properties, and other non-opioid analgesics. This combination is used for the management of moderate to severe pain where the use of a combination therapy is considered appropriate. This drug combination is approved and marketed in some countries under various brand names.
Estimated pharmacokinetic parameters for healthy adults, typical oral fixed-dose product combining tramadol and a non-opioid analgesic. No specific population PK studies reported for the combination.
Coller, JK, et al., & Somogyi, AA (2012). Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients. British journal of clinical pharmacology 74(5) 835–841. DOI:10.1111/j.1365-2125.2012.04256.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/22369095