.Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AJ22_HydrocodoneAndParacetamo.HydrocodoneAndParacetamo .Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AJ22_HydrocodoneAndParacetamo.HydrocodoneAndParacetamo| name: | HydrocodoneAndParacetamol | |
| ATC code: | N02AJ22 | route: | oral |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 20 | L |
| clearance: | 7.9 | L/h |
| other parameters in model implementation | ||
Hydrocodone and paracetamol (acetaminophen) is a combination opioid analgesic containing a semi-synthetic opioid (hydrocodone) and a non-opioid analgesic (paracetamol/acetaminophen). This combination is used for the relief of moderate to severe pain and is approved for clinical use in a number of countries, though increasing regulatory restrictions exist due to dependence and hepatotoxicity potential.
Pharmacokinetic parameters reported in healthy adult volunteers, fasted state, after a single oral dose of hydrocodone 10 mg/paracetamol 650 mg tablet.
Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834