.Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AJ23_HydrocodoneAndIbuprofen.HydrocodoneAndIbuprofen .Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AJ23_HydrocodoneAndIbuprofen.HydrocodoneAndIbuprofen| name: | HydrocodoneAndIbuprofen |
| ATC code: | N02AJ23 | route: | oral |
| n-compartments | 1 |
Hydrocodone and ibuprofen is a combination drug used to treat moderate to severe pain where treatment with an opioid is appropriate and for which alternative treatments are inadequate. Hydrocodone is a semi-synthetic opioid analgesic, and ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). The fixed combination is approved for short-term management of acute pain in adults. Hydrocodone acts as a mu-opioid receptor agonist, and ibuprofen acts by inhibiting prostaglandin synthesis via non-selective cyclooxygenase (COX) inhibition.
Pharmacokinetics after single oral administration of a fixed-dose combination (hydrocodone 7.5 mg/ibuprofen 200 mg) in healthy adults.
Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834