.Pharmacolibrary.Drugs.N_NervousSystem.N02A_Opioids.N02AX06_Tapentadol.Tapentadol

Information

Tapentadol is a centrally acting opioid analgesic used for the management of moderate to severe acute pain and chronic pain. It is a mu-opioid receptor agonist and a norepinephrine reuptake inhibitor. Tapentadol is approved and in use today for pain management in various countries.

Pharmacokinetics

Pharmacokinetic parameters as reported in healthy adult volunteers following oral immediate-release tapentadol.

References

1. Khalil, F, et al., & Freijer, J (2020). Population Pharmacokinetics of Tapentadol in Children from Birth to <18 Years Old. Journal of pain research 13 3107–3123. DOI:10.2147/JPR.S269549 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33262645

2. Jończyk, R, et al., & Khalil, F (2022). Multiple Dose Pharmacokinetics of Tapentadol Oral Solution for the Treatment of Moderate to Severe Acute Pain in Children Aged 2 to <7 Years. Journal of pain research 15 3103–3114. DOI:10.2147/JPR.S364902 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36203787

3. Xu, XS, et al., & Nandy, P (2010). Population pharmacokinetics of tapentadol immediate release (IR) in healthy subjects and patients with moderate or severe pain. Clinical pharmacokinetics 49(10) 671–682. DOI:10.2165/11535390-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20818833

Revisions

• 06/2025 initial generated model