.Pharmacolibrary.Drugs.N_NervousSystem.N02B_OtherAnalgesicsAndAntipyretics.N02BE01_Paracetamol.Paracetamol

Information

Paracetamol, also known as acetaminophen, is a widely used analgesic and antipyretic medication for the relief of fever and mild to moderate pain. It is approved for over-the-counter and prescription use globally and is considered safe when used at recommended doses.

Pharmacokinetics

Pharmacokinetic parameters for healthy adult individuals after single oral dose administration.

References

1. Forrest, JA, et al., & Prescott, LF (1982). Clinical pharmacokinetics of paracetamol. Clinical pharmacokinetics 7(2) 93–107. DOI:10.2165/00003088-198207020-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7039926

2. Moore, RA, et al., & Straube, S (2015). Effects of food on pharmacokinetics of immediate release oral formulations of aspirin, dipyrone, paracetamol and NSAIDs - a systematic review. British journal of clinical pharmacology 80(3) 381–388. DOI:10.1111/bcp.12628 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25784216

3. van der Heijden, LT, et al., & Spriet, I (2022). Highly Variable Paracetamol Pharmacokinetics After Multiple Oral Dosing in Frail Older People: A Population Pharmacokinetic Analysis. Drugs & aging 39(1) 83–95. DOI:10.1007/s40266-021-00912-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/34918212

Revisions

• 06/2025 initial generated model