.Pharmacolibrary.Drugs.N_NervousSystem.N02B_OtherAnalgesicsAndAntipyretics.N02BE03_Phenacetin.Phenacetin

Information

name:Phenacetin
ATC code:N02BE03
route:oral
n-compartments1

Phenacetin is an analgesic and antipyretic drug, formerly widely used for the relief of pain and fever. It has largely been withdrawn and is no longer approved or used today in most countries due to its association with nephrotoxicity and carcinogenicity.

Pharmacokinetics

Pharmacokinetic parameters for healthy adult volunteers after a single oral dose.

References

  1. Bartoli, A, et al., & Perucca, E (1996). The influence of ethnic factors and gender on CYP1A2-mediated drug disposition: a comparative study in Caucasian and Chinese subjects using phenacetin as a marker substrate. Therapeutic drug monitoring 18(5) 586–591. DOI:10.1097/00007691-199610000-00011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8885124

  2. Barter, ZE, et al., & Rowland-Yeo, K (2013). Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based pharmacokinetic modelling. Clinical pharmacokinetics 52(12) 1085–1100. DOI:10.1007/s40262-013-0089-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/23818090

  3. Song, JJ, et al., & Yin, WY (2015). Quantitative determination of fluconazole by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) in human plasma and its application to a pharmacokinetic study. Drug research 65(1) 52–56. DOI:10.1055/s-0034-1384610 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25093302

Revisions


Generated at 2025-07-20T18:21:09Z by OpenModelicaOpenModelica 1.25.1 using GenerateDoc.mos