.Pharmacolibrary.Drugs.N_NervousSystem.N02C_AntimigrainePreparations.N02CX02_Clonidine.Clonidine

Information

name:Clonidine
ATC code:N02CX02
route:oral
n-compartments2

Clonidine is an alpha-2 adrenergic agonist used for the treatment of hypertension, attention deficit hyperactivity disorder (ADHD), and occasionally for management of withdrawal symptoms or pain. It remains approved and in use for these indications today.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after oral tablet administration.

References

  1. Larsson, P, et al., & Anderson, BJ (2011). Oral bioavailability of clonidine in children. Paediatric anaesthesia 21(3) 335–340. DOI:10.1111/j.1460-9592.2010.03397.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/20735802

  2. De Hondt, L, et al., & Tommelein, E (2024). Quantification of ADHD medication in biological fluids of pregnant and breastfeeding women with liquid chromatography: a comprehensive review. Frontiers in public health 12 1437328–None. DOI:10.3389/fpubh.2024.1437328 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39171321

  3. Bienert, A, et al., & Grześkowiak, E (2015). Melatonin and clonidine premedication has similar impact on the pharmacokinetics and pharmacodynamics of propofol target controlled-infusions. Journal of clinical pharmacology 55(3) 307–316. DOI:10.1002/jcph.401 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25243731

Revisions


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