.Pharmacolibrary.Drugs.N_NervousSystem.N03A_Antiepileptics.N03AB52_PhenytoinCombinations.PhenytoinCombinations

Information

name:PhenytoinCombinations
ATC code:N03AB52
route:oral
n-compartments1

Phenytoin is an antiepileptic drug primarily used for the prevention and control of seizures, especially in the treatment of generalized tonic-clonic (grand mal) and complex partial seizures. Combinations of phenytoin with other drugs (ATC N03AB52) are sometimes used when polytherapy is needed for seizure control. Phenytoin is currently approved and widely used in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters estimated for a typical adult patient (age 18-65 years) with epilepsy taking phenytoin combination therapy, based on average data reported for phenytoin oral administration. No specific published population PK data available for phenytoin combinations under ATC N03AB52; estimates based on standard adult data for phenytoin monotherapy.

References

  1. Li, ZD, et al., & Huang, YA (2016). Population Pharmacokinetics of Phenytoin Based on NONMEM in Patients with Intracranial Tumor During the First Week of Post-Craniotomy. Current drug metabolism 17(7) 721–728. DOI:10.2174/1389200217666160513132716 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27174459

  2. Mungall, DR, et al., & Crawford, MH (1985). Population pharmacokinetics of racemic warfarin in adult patients. Journal of pharmacokinetics and biopharmaceutics 13(3) 213–227. DOI:10.1007/BF01065653 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3841364

  3. Graves, NM, et al., & Leppik, IE (1998). Population pharmacokinetics of carbamazepine in adults with epilepsy. Pharmacotherapy 18(2) 273–281. PUBMED:https://pubmed.ncbi.nlm.nih.gov/9545146

Revisions


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