.Pharmacolibrary.Drugs.N_NervousSystem.N03A_Antiepileptics.N03AX18_Lacosamide.Lacosamide

Information

name:Lacosamide
ATC code:N03AX18
route:oral
n-compartments1

Lacosamide is an antiepileptic drug (AED) approved for the treatment of partial-onset seizures in patients with epilepsy. It acts by enhancing the slow inactivation of voltage-gated sodium channels, stabilizing hyperexcitable neuronal membranes. Lacosamide is used as adjunctive therapy or monotherapy in adults and children, and is generally well-tolerated.

Pharmacokinetics

Pharmacokinetics in healthy adult volunteers after oral administration at steady state.

References

  1. Jacob, S, & Nair, AB (2016). An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs. Drugs in R&D 16(4) 303–316. DOI:10.1007/s40268-016-0148-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27766590

  2. Hoy, SM (2018). Lacosamide: A Review in Focal-Onset Seizures in Patients with Epilepsy. CNS drugs 32(5) 473–484. DOI:10.1007/s40263-018-0523-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29785508

  3. Verrotti, A, et al., & Zaccara, G (2012). Lacosamide in patients with pharmacoresistant epilepsy. Expert opinion on pharmacotherapy 13(14) 2065–2072. DOI:10.1517/14656566.2012.713347 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22873760

Revisions


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