.Pharmacolibrary.Drugs.N_NervousSystem.N04B_DopaminergicAgents.N04BA02_LevodopaAndDecarboxylaseInhibito.LevodopaAndDecarboxylaseInhibito_1

Information

name:LevodopaAndDecarboxylaseInhibitor_1
ATC code:N04BA02_1
route:oral
n-compartments1

Levodopa and decarboxylase inhibitor is a combination drug used in the management of Parkinson's disease. Levodopa is a precursor of dopamine, which is deficient in patients with Parkinson's disease, and the decarboxylase inhibitor (usually carbidopa) prevents the peripheral breakdown of levodopa, increasing its availability to the brain. This therapy is widely used and approved in clinical practice.

Pharmacokinetics

Pharmacokinetic parameters for healthy adults receiving single oral dose of levodopa/carbidopa (100 mg/25 mg).

References

  1. Rouru, J, et al., & Scheinin, M (1999). Pharmacokinetics of oral entacapone after frequent multiple dosing and effects on levodopa disposition. European journal of clinical pharmacology 55(6) 461–467. DOI:10.1007/s002280050657 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10492060

  2. Bianchine, JR, & Shaw, GM (1976). Clinical pharmacokinetics of levodopa in parkinson's disease. Clinical pharmacokinetics 1(5) 313–338. DOI:10.2165/00003088-197601050-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/797502

  3. Scott, LJ (2016). Opicapone: A Review in Parkinson's Disease. Drugs 76(13) 1293–1300. DOI:10.1007/s40265-016-0623-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/27498199

Revisions


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