.Pharmacolibrary.Drugs.N_NervousSystem.N05A_Antipsychotics.N05AA01_Chlorpromazine.Chlorpromazine

Information

Chlorpromazine is a typical antipsychotic drug of the phenothiazine class, historically used for the treatment of schizophrenia, psychotic disorders, severe nausea and vomiting, and intractable hiccups. Though still in clinical use in some countries, it has largely been replaced by atypical antipsychotics due to its side effect profile.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after single oral administration.

References

1. Yonkers, KA, et al., & Blumenthal, S (1992). Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. The American journal of psychiatry 149(5) 587–595. DOI:10.1176/ajp.149.5.587 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1575248

2. Chetty, M, & Miller, R (2001). Oral contraceptives increase the plasma concentrations of chlorpromazine. Therapeutic drug monitoring 23(5) 556–558. DOI:10.1097/00007691-200110000-00011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11591904

3. Stephen, LJ (2003). Drug treatment of epilepsy in elderly people: focus on valproic Acid. Drugs & aging 20(2) 141–152. DOI:10.2165/00002512-200320020-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12534314

Revisions

• 06/2025 initial generated model