.Pharmacolibrary.Drugs.N_NervousSystem.N05B_Anxiolytics.N05BA16_Nordazepam.Nordazepam

Information

Nordazepam (desmethyldiazepam) is a benzodiazepine derivative acting as an anxiolytic and sedative. It is a metabolite of diazepam, chlordiazepoxide, and others. While not widely prescribed as a standalone drug today, it is still detected in patients as a result of metabolism of other benzodiazepines. It is not typically approved for standalone use in many countries.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after oral administration.

References

1. Wang, LL, et al., & Yun, KM (2020). An Experimental Pharmacokinetics Study of Diazepam and Its Metabolites in Oral Fluid of Chinese Population. Journal of analytical toxicology 44(4) 348–353. DOI:10.1093/jat/bkz101 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31965188

2. Wang, LL, et al., & Yun, KM (2020). Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People. European journal of drug metabolism and pharmacokinetics 45(4) 477–485. DOI:10.1007/s13318-020-00614-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32219697

3. Sohn, DR, et al., & Chiba, K (1992). Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. Clinical pharmacology and therapeutics 52(2) 160–169. DOI:10.1038/clpt.1992.125 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1505151

Revisions

• 06/2025 initial generated model